Name | 8-M-PDOT |
Synonyms | AH 002 8-M-PDOT 8-METHOXY-2-PROPIONAMIDOTETRALIN |
CAS | 134865-70-6 |
Molecular Formula | C14H19NO2 |
Molar Mass | 233.31 |
Storage Condition | Store at RT |
biological activity | 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold more selective for MT2 than the MT1 receptor. 8-M-PDOT binds to human recombinant MT1 and MT2 receptors with pKi values of 8.23 and 8.95, respectively. 8-M-PDOT has anti-Anxiety activity. |
Target | pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor) |
Animal Model: | Male Wistar rats (280-320 g) with Rotenone |
Dosage: | 10 µg/µL |
Administration: | Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes |
Result: | Increased percentage of time spent in the open arms and in the number of open arms entries. |